1BGO

CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR

1BGO の概要

• エントリーDOI: 10.2210/pdb1bgo/pdb
• 分子名称: CATHEPSIN K, 1-[2-(3-BIPHENYL)-4-METHYLVALERYL)]AMINO-3-(2-PYRIDYLSULFONYL)AMINO-2-PROPANONE (3 entities in total)
• 機能のキーワード: hydrolase, sulfhydryl proteinase, thiol protease
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P43235
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24005.09

構造登録者

Desjarlais, R.L.,Yamashita, D.S.,Oh, H.-J.,Bondinell, W.E.,Uzinskas, I.N.,Erhard, K.F.,Allen, A.C.,Haltiwanger, R.C.,Zhao, B.,Smith, W.W.,Abdel-Meguid, S.S.,D'Alessio, K.,Janson, C.A.,Mcqueney, M.S.,Tomaszek, T.A.,Levy, M.A.,Veber, D.F. (登録日: 1998-05-29, 公開日: 1999-06-08, 最終更新日: 2023-08-02)

• 主引用文献: Desjarlais, R.L.,Yamashita, D.S.,Oh, H.J.,Uzinskas, I.N.,Erhard, K.F.,Allen, A.C.,Haltiwanger, R.C.,Zhao, B.G.,Smith, W.W.,Abdel-Meguid, S.S.,Dalessio, K.,Janson, C.A.,Mcqueney, M.S.,Tomaszek, T.A.,Levy, M.A.,Veber, D.F.; Use of X-Ray Co-Crystal Structures and Molecular Modeling to Design Potent and Selective Non-Peptide Inhibitors of Cathepsin K; J.Am.Chem.Soc., 120:9114-, 1998

実験手法

X-RAY DIFFRACTION (2.3 Å)