1BF8

PERIPLASMIC CHAPERONE FIMC, NMR, 20 STRUCTURES

1BF8 の概要

• エントリーDOI: 10.2210/pdb1bf8/pdb
• 分子名称: CHAPERONE PROTEIN FIMC (1 entity in total)
• 機能のキーワード: chaperone, fimc, periplasmic chaperone, pilus chaperone, type-i pili
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22754.03

構造登録者

Pellecchia, M.,Guntert, P.,Glockshuber, R.,Wuthrich, K. (登録日: 1998-05-28, 公開日: 1998-11-18, 最終更新日: 2024-05-22)

主引用文献

Pellecchia, M.,Guntert, P.,Glockshuber, R.,Wuthrich, K.
NMR solution structure of the periplasmic chaperone FimC.
Nat.Struct.Biol., 5:885-890, 1998

PubMed Abstract: The NMR structure of the 205-residue periplasmic chaperone FimC is presented. This protein consists of two globular domains with immunoglobulin-like folds connected by a 15-residue linker peptide. The relative orientation of the two domains is defined by hydrophobic contacts and an interdomain salt bridge. FimC mediates the assembly of type-1 pili, which are filamentous surface organelles of uropathogenic Escherichia coli strains that enable the bacteria to attach to host cell surfaces and persist in macrophages. The availability of the NMR structure of FimC provides a new basis for rational design of drugs against infections by uropathogenic bacteria.

PubMed: 9783748
DOI: 10.1038/2325

実験手法

SOLUTION NMR