1BDO

STRUCTURE OF THE BIOTINYL DOMAIN OF ACETYL-COENZYME A CARBOXYLASE DETERMINED BY MAD PHASING

1BDO の概要

• エントリーDOI: 10.2210/pdb1bdo/pdb
• 分子名称: ACETYL-COA CARBOXYLASE, BIOTIN (3 entities in total)
• 機能のキーワード: bccpsc, carboxyl transferase, fatty acid biosynthesis, hammerhead structure, selenomethionine, ligase, transferase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8944.33

構造登録者

Athappilly, F.K.,Hendrickson, W.A. (登録日: 1995-11-21, 公開日: 1996-08-01, 最終更新日: 2024-10-23)

主引用文献

Athappilly, F.K.,Hendrickson, W.A.
Structure of the biotinyl domain of acetyl-coenzyme A carboxylase determined by MAD phasing.
Structure, 3:1407-1419, 1995

PubMed Abstract: Acetyl-coenzyme A carboxylase catalyzes the first committed step of fatty acid biosynthesis. Universally, this reaction involves three functional components all related to a carboxybiotinyl intermediate. A biotinyl domain shuttles its covalently attached biotin prosthetic group between the active sites of a biotin carboxylase and a carboxyl transferase. In Escherichia coli, the three components reside in separate subunits: a biotinyl domain is the functional portion of one of these, biotin carboxy carrier protein (BCCP).

PubMed: 8747466
DOI: 10.1016/S0969-2126(01)00277-5

実験手法

X-RAY DIFFRACTION (1.8 Å)