1BAU
NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE
Summary for 1BAU
| Entry DOI | 10.2210/pdb1bau/pdb |
| Descriptor | SL1 RNA DIMER (1 entity in total) |
| Functional Keywords | ribonucleic acid, hiv-1, dimerization, encapsidation, rna |
| Total number of polymer chains | 2 |
| Total formula weight | 14834.98 |
| Authors | Mujeeb, A.,Clever, J.L.,Billeci, T.M.,James, T.L.,Parslow, T.G. (deposition date: 1998-04-18, release date: 1999-04-27, Last modification date: 2024-05-22) |
| Primary citation | Mujeeb, A.,Clever, J.L.,Billeci, T.M.,James, T.L.,Parslow, T.G. Structure of the dimer initiation complex of HIV-1 genomic RNA. Nat.Struct.Biol., 5:432-436, 1998 Cited by PubMed Abstract: Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and metastable, its interface being formed not only by standard basepairing between palindromes, but also by a distinctive pattern of interstrand stacking among bases at the stem-loop junctions. This creates mechanical distortions that partially melt both stems, which may facilitate spontaneous refolding of this RNA complex into linear form. PubMed: 9628479DOI: 10.1038/nsb0698-432 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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