1BAE

STRUCTURE OF DNA (5'-D 5MCCTTTACC-3')2, NMR, 1 STRUCTURE

1BAE の概要

• エントリーDOI: 10.2210/pdb1bae/pdb
• 分子名称: DNA (5'-D(*MCYP*CP*TP*TP*TP*AP*CP*C)-3') (1 entity in total)
• 機能のキーワード: deoxyribonucleic acid, dna dimer of 5mcctttacc, i-motif, dimer, dna
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 4543.20

構造登録者

Nonin, S.,Tuan, A.P.,Leroy, J.L. (登録日: 1997-07-28, 公開日: 1998-01-14, 最終更新日: 2024-04-10)

主引用文献

Nonin, S.,Phan, A.T.,Leroy, J.L.
Solution structure and base pair opening kinetics of the i-motif dimer of d(5mCCTTTACC): a noncanonical structure with possible roles in chromosome stability.
Structure, 5:1231-1246, 1997

PubMed Abstract: Repetitive cytosine-rich DNA sequences have been identified in telomeres and centromeres of eukaryotic chromosomes. These sequences play a role in maintaining chromosome stability during replication and may be involved in chromosome pairing during meiosis. The C-rich repeats can fold into an 'i-motif' structure, in which two parallel-stranded duplexes with hemiprotonated C.C+ pairs are intercalated. Previous NMR studies of naturally occurring repeats have produced poor NMR spectra. This led us to investigate oligonucleotides, based on natural sequences, to produce higher quality spectra and thus provide further information as to the structure and possible biological function of the i-motif.

PubMed: 9331414
DOI: 10.1016/S0969-2126(97)00273-6

実験手法

SOLUTION NMR