1B9V

NOVEL AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE MAKE SELECTIVE INTERACTIONS WITH CONSERVED RESIDUES AND WATER MOLECULES IN TEH ACTIVE SITE

1B9V の概要

• エントリーDOI: 10.2210/pdb1b9v/pdb
• 分子名称: PROTEIN (NEURAMINIDASE), 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: influenza, neuraminidase, sialidase, b/lee/40, hydrolase
• 由来する生物種: Influenza B virus (B/Lee/40)
• 細胞内の位置: Virion membrane (By similarity): P03474
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44112.12

構造登録者

Finley, J.B.,Atigadda, V.R.,Duarte, F.,Zahao, J.J.,Brouillette, W.J.,Air, G.M.,Luo, M. (登録日: 1999-02-15, 公開日: 1999-02-27, 最終更新日: 2023-08-09)

• 主引用文献: Finley, J.B.,Atigadda, V.R.,Duarte, F.,Zhao, J.J.,Brouillette, W.J.,Air, G.M.,Luo, M.; Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water molecules in the active site.; J.Mol.Biol., 293:1107-1119, 1999; PubMed: 10547289; DOI: 10.1006/jmbi.1999.3180

実験手法

X-RAY DIFFRACTION (2.35 Å)