1B8W

DEFENSIN-LIKE PEPTIDE 1

1B8W の概要

• エントリーDOI: 10.2210/pdb1b8w/pdb
• 分子名称: PROTEIN (DEFENSIN-LIKE PEPTIDE 1) (1 entity in total)
• 機能のキーワード: toxin, platypus
• 由来する生物種: Ornithorhynchus anatinus (platypus)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4968.68

構造登録者

Torres, A.M.,Wang, X.,Fletcher, J.I.,Alewood, D.,Alewood, P.F.,Smith, R.,Simpson, R.J.,Nicholson, G.M.,Sutherland, S.K.,Gallagher, C.H.,King, G.F.,Kuchel, P.W. (登録日: 1999-02-02, 公開日: 1999-09-15, 最終更新日: 2024-10-16)

主引用文献

Torres, A.M.,Wang, X.,Fletcher, J.I.,Alewood, D.,Alewood, P.F.,Smith, R.,Simpson, R.J.,Nicholson, G.M.,Sutherland, S.K.,Gallagher, C.H.,King, G.F.,Kuchel, P.W.
Solution structure of a defensin-like peptide from platypus venom.
Biochem.J., 341:785-794, 1999

PubMed Abstract: Three defensin-like peptides (DLPs) were isolated from platypus venom and sequenced. One of these peptides, DLP-1, was synthesized chemically and its three-dimensional structure was determined using NMR spectroscopy. The main structural elements of this 42-residue peptide were an anti-parallel beta-sheet comprising residues 15-18 and 37-40 and a small 3(10) helix spanning residues 10-12. The overall three-dimensional fold is similar to that of beta-defensin-12, and similar to the sodium-channel neurotoxin ShI (Stichodactyla helianthus neurotoxin I). However, the side chains known to be functionally important in beta-defensin-12 and ShI are not conserved in DLP-1, suggesting that it has a different biological function. Consistent with this contention, we showed that DLP-1 possesses no anti-microbial properties and has no observable activity on rat dorsal-root-ganglion sodium-channel currents.

PubMed: 10417345
DOI: 10.1042/0264-6021:3410785

実験手法

SOLUTION NMR