1B6U

CRYSTAL STRUCTURE OF THE HUMAN KILLER CELL INHIBITORY RECEPTOR (KIR2DL3) SPECIFIC FOR HLA-CW3 RELATED ALLELES

1B6U の概要

• エントリーDOI: 10.2210/pdb1b6u/pdb
• 分子名称: P58 KILLER CELL INHIBITORY RECEPTOR (1 entity in total)
• 機能のキーワード: killer cell inhibitory receptor, natural killer cell, hla, major histocompatibility complex class i (mhc class i), cell surface receptor, immunoglobulin superfamily
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28189.14

構造登録者

Maenaka, K.,Juji, T.,Stuart, D.I.,Jones, E.Y. (登録日: 1999-01-18, 公開日: 1999-01-27, 最終更新日: 2024-11-20)

主引用文献

Maenaka, K.,Juji, T.,Stuart, D.I.,Jones, E.Y.
Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I.
Structure Fold.Des., 7:391-398, 1999

PubMed Abstract: T cells and natural killer (NK) cells perform complementary roles in the cellular immune system. T cells identify infected cells directly through recognition of antigenic peptides that are displayed at the target cell surface by the classical major histocompatibility complex (MHC) class I molecules. NK cells monitor the target cell surface for malfunction of this display system, lysing potentially infected cells that might otherwise evade recognition by the T cells. Human killer cell inhibitory receptors (KIRs) control this process by either inhibiting or activating the cytotoxic activity of NK cells via specific binding to MHC class I molecules on the target cell.

PubMed: 10196125
DOI: 10.1016/S0969-2126(99)80052-5

実験手法

X-RAY DIFFRACTION (3 Å)