1B6P

HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7

Summary for 1B6P

Related1B6J 1B6K 1B6M 1B6N 1B6O 1B6L
DescriptorRETROPEPSIN, SULFATE ION, N-[3-(8-SEC-BUTYL-7,10-DIOXO-2-OXA-6,9-DIAZA-BICYCLO[11.2.2] HEPTADECA-1(16),13(17),14-TRIEN-11-YAMINO)-2-HYDROXY-1-(4-HYDROXY-BENZYL) -PROPYL]-3-METHYL-2-PROPIONYLAMINO-BUTYRAMIDE, ... (4 entities in total)
Functional Keywordscomplex (acid proteinase-peptide), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P03369
Total number of polymer chains2
Total molecular weight22487.4
Authors
Primary citation
Martin, J.L.,Begun, J.,Schindeler, A.,Wickramasinghe, W.A.,Alewood, D.,Alewood, P.F.,Bergman, D.A.,Brinkworth, R.I.,Abbenante, G.,March, D.R.,Reid, R.C.,Fairlie, D.P.
Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38:7978-7988, 1999
PubMed: 10387041 (PDB entries with the same primary citation)
DOI: 10.1021/bi990174x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.239401.3%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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