1B6M

HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 6

1B6M の概要

• エントリーDOI: 10.2210/pdb1b6m/pdb
• 関連するPDBエントリー: 1B6J 1B6K 1B6L 1B6N 1B6O 1B6P
• 関連するBIRD辞書のPRD_ID: PRD_000269
• 分子名称: RETROPEPSIN, SULFATE ION, [1-BENZYL-3-(8-SEC-BUTYL-7,10-DIOXO-2-OXA-6,9-DIAZA-BICYCLO[11.2.2] HEPTADECA-1(16),13(17),14-TRIEN-11-YLAMINO)-2-HYDROXY-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER, ... (4 entities in total)
• 機能のキーワード: complex (acid proteinase-peptide), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03369
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22416.32

構造登録者

Martin, J.L.,Begun, J.,Schindeler, A.,Wickramasinghe, W.A.,Alewood, D.,Alewood, P.F.,Bergman, D.A.,Brinkworth, R.I.,Abbenante, G.,March, D.R.,Reid, R.C.,Fairlie, D.P. (登録日: 1999-01-17, 公開日: 2000-01-07, 最終更新日: 2023-11-15)

• 主引用文献: Martin, J.L.,Begun, J.,Schindeler, A.,Wickramasinghe, W.A.,Alewood, D.,Alewood, P.F.,Bergman, D.A.,Brinkworth, R.I.,Abbenante, G.,March, D.R.,Reid, R.C.,Fairlie, D.P.; Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.; Biochemistry, 38:7978-7988, 1999; PubMed: 10387041; DOI: 10.1021/bi990174x

実験手法

X-RAY DIFFRACTION (1.85 Å)