1B3P

5'-D(*GP*GP*AP*GP*GP*AP*T)-3'

Summary for 1B3P

• Entry DOI: 10.2210/pdb1b3p/pdb
• Descriptor: DNA (5'-D(*GP*GP*AP*GP*GP*AP*T)-3') (1 entity in total)
• Functional Keywords: (g-g-a) triplet repeat; v-shaped backbone; parallel-stranded segments; mismatch alignments; uniform 13c, 15n-labeled dna, dna
• Total number of polymer chains: 2
• Total formula weight: 4404.94

Authors

Kettani, A.,Bouaziz, S.,Skripkin, E.,Majumdar, A.,Wang, W.,Jones, R.A.,Patel, D.J. (deposition date: 1998-12-14, release date: 1999-08-31, Last modification date: 2023-12-27)

Primary citation

Kettani, A.,Bouaziz, S.,Skripkin, E.,Majumdar, A.,Wang, W.,Jones, R.A.,Patel, D.J.
Interlocked mismatch-aligned arrowhead DNA motifs.
Structure Fold.Des., 7:803-815, 1999

PubMed Abstract: Triplet repeat sequences are of considerable biological importance as the expansion of such tandem arrays can lead to the onset of a range of human diseases. Such sequences can self-pair via mismatch alignments to form higher order structures that have the potential to cause replication blocks, followed by strand slippage and sequence expansion. The all-purine d(GGA)n triplet repeat sequence is of particular interest because purines can align via G.G, A.A and G.A mismatch formation.

PubMed: 10425682
DOI: 10.1016/S0969-2126(99)80104-X

Experimental method

SOLUTION NMR