1B3A
TOTAL CHEMICAL SYNTHESIS AND HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE POTENT ANTI-HIV PROTEIN AOP-RANTES
Summary for 1B3A
| Entry DOI | 10.2210/pdb1b3a/pdb |
| Descriptor | PROTEIN (RANTES), SULFATE ION, PENTYLOXYAMINO-ACETALDEHYDE, ... (4 entities in total) |
| Functional Keywords | chemical protein synthesis, chemokine, hiv-1, rantes, anti-hiv protein |
| Cellular location | Secreted: P13501 |
| Total number of polymer chains | 2 |
| Total formula weight | 16224.52 |
| Authors | Wilken, J.,Hoover, D.,Thompson, D.A.,Barlow, P.N.,Mcsparron, H.,Picard, L.,Wlodawer, A.,Lubkowski, J.,Kent, S.B.H. (deposition date: 1998-12-07, release date: 1999-04-23, Last modification date: 2024-10-30) |
| Primary citation | Wilken, J.,Hoover, D.,Thompson, D.A.,Barlow, P.N.,McSparron, H.,Picard, L.,Wlodawer, A.,Lubkowski, J.,Kent, S.B. Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein AOP-RANTES. Chem.Biol., 6:43-51, 1999 Cited by PubMed Abstract: RANTES is a CC-type chemokine protein that acts as a chemoattractant for several kinds of leukocytes, playing an important pro-inflammatory role. Entry of human immunodeficiency virus-1 (HIV-1) into cells depends on the chemokine receptor CCR5. RANTES binds CCR5 and inhibits HIV-1 entry into peripheral blood cells. Interaction with chemokine receptors involves a distinct set of residues at the amino terminus of RANTES. This finding was utilized in the development of a chemically modified aminooxypentane derivative of RANTES, AOP-RANTES, that was originally produced from the recombinant protein using semisynthetic methods. PubMed: 9889151DOI: 10.1016/S1074-5521(99)80019-2 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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