1B3A

TOTAL CHEMICAL SYNTHESIS AND HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE POTENT ANTI-HIV PROTEIN AOP-RANTES

1B3A の概要

• エントリーDOI: 10.2210/pdb1b3a/pdb
• 分子名称: PROTEIN (RANTES), SULFATE ION, PENTYLOXYAMINO-ACETALDEHYDE, ... (4 entities in total)
• 機能のキーワード: chemical protein synthesis, chemokine, hiv-1, rantes, anti-hiv protein
• 細胞内の位置: Secreted: P13501
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 16224.52

構造登録者

Wilken, J.,Hoover, D.,Thompson, D.A.,Barlow, P.N.,Mcsparron, H.,Picard, L.,Wlodawer, A.,Lubkowski, J.,Kent, S.B.H. (登録日: 1998-12-07, 公開日: 1999-04-23, 最終更新日: 2024-10-30)

主引用文献

Wilken, J.,Hoover, D.,Thompson, D.A.,Barlow, P.N.,McSparron, H.,Picard, L.,Wlodawer, A.,Lubkowski, J.,Kent, S.B.
Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein AOP-RANTES.
Chem.Biol., 6:43-51, 1999

PubMed Abstract: RANTES is a CC-type chemokine protein that acts as a chemoattractant for several kinds of leukocytes, playing an important pro-inflammatory role. Entry of human immunodeficiency virus-1 (HIV-1) into cells depends on the chemokine receptor CCR5. RANTES binds CCR5 and inhibits HIV-1 entry into peripheral blood cells. Interaction with chemokine receptors involves a distinct set of residues at the amino terminus of RANTES. This finding was utilized in the development of a chemically modified aminooxypentane derivative of RANTES, AOP-RANTES, that was originally produced from the recombinant protein using semisynthetic methods.

PubMed: 9889151
DOI: 10.1016/S1074-5521(99)80019-2

実験手法

X-RAY DIFFRACTION (1.6 Å)