1B37

A 30 ANGSTROM U-SHAPED CATALYTIC TUNNEL IN THE CRYSTAL STRUCTURE OF POLYAMINE OXIDASE

1B37 の概要

• エントリーDOI: 10.2210/pdb1b37/pdb
• 分子名称: PROTEIN (POLYAMINE OXIDASE), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-D-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: flavin-dependent amine oxidase, oxidoreductase
• 由来する生物種: Zea mays
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 165195.65

構造登録者

Binda, C.,Coda, A.,Angelini, R.,Federico, R.,Ascenzi, P.,Mattevi, A. (登録日: 1998-12-17, 公開日: 1999-12-17, 最終更新日: 2024-11-06)

主引用文献

Binda, C.,Coda, A.,Angelini, R.,Federico, R.,Ascenzi, P.,Mattevi, A.
A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase.
Structure Fold.Des., 7:265-276, 1999

PubMed Abstract: Polyamines are essential for cell growth and differentiation; compounds interfering with their metabolism are potential anticancer agents. Polyamine oxidase (PAO) plays a central role in polyamine homeostasis. The enzyme utilises an FAD cofactor to catalyse the oxidation of the secondary amino groups of spermine and spermidine.

PubMed: 10368296
DOI: 10.1016/S0969-2126(99)80037-9

実験手法

X-RAY DIFFRACTION (1.9 Å)