1B2V

HEME-BINDING PROTEIN A

1B2V の概要

• エントリーDOI: 10.2210/pdb1b2v/pdb
• 分子名称: PROTEIN (HEME-BINDING PROTEIN A), CALCIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
• 機能のキーワード: heme acquisition, iron metabolism, transport protein
• 由来する生物種: Serratia marcescens
• 細胞内の位置: Secreted : Q54450
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19945.20

構造登録者

Arnoux, P.,Haser, R.,Izadi, N.,Lecroisey, A.,Wandersma, N.C.,Czjzek, M. (登録日: 1998-12-01, 公開日: 1999-06-24, 最終更新日: 2023-12-27)

主引用文献

Arnoux, P.,Haser, R.,Izadi, N.,Lecroisey, A.,Delepierre, M.,Wandersman, C.,Czjzek, M.
The crystal structure of HasA, a hemophore secreted by Serratia marcescens.
Nat.Struct.Biol., 6:516-520, 1999

PubMed Abstract: Free iron availability is strongly limited in vertebrate hosts, making the iron acquisition by siderophores inappropriate. Pathogenic bacteria have developed various ways to use the host's iron from iron-containing proteins. Serratia marcescens can use the iron from hemoglobin through the secretion of a hemophore called HasA, which takes up the heme from hemoglobin and shuttles it to the receptor HasR, which in turn, releases heme into the bacterium. We report here the first crystal structure of such a hemophore, bound to a heme group at two different pH values and at a resolution of 1.9 A. The structure reveals a new original fold and suggests a hypothetical mechanism for both heme uptake and release.

PubMed: 10360351
DOI: 10.1038/9281

実験手法

X-RAY DIFFRACTION (1.9 Å)