1B18

PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.53 COORDINATES)

1B18 の概要

• エントリーDOI: 10.2210/pdb1b18/pdb
• 関連するPDBエントリー: 1B17 1B18 1B19 1B2A 1B2B 1B2C 1B2D 1B2E 1B2F 1B2G
• 分子名称: PROTEIN (INSULIN a chain), PROTEIN (INSULIN b chain), SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hormone, glucose concentration decrease, hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Sus scrofa (pig); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 5883.69

構造登録者

Diao, J.S.,Caspar, D.L.D. (登録日: 1998-11-26, 公開日: 2003-04-08, 最終更新日: 2024-11-13)

主引用文献

Diao, J.
Crystallographic titration of cubic insulin crystals: pH affects GluB13 switching and sulfate binding.
Acta Crystallogr.,Sect.D, 59:670-676, 2003

PubMed Abstract: Structures of porcine insulin crystals soaked in 1 M sodium sulfate at pH 5.00, 5.53, 5.80, 6.00, 6.16, 6.26, 6.35, 6.50, 6.98 and 9.00 have been determined at between 1.7 and 1.9 A resolution. GluB13 exhibits a single conformation at pH PubMed: 12657786
DOI: 10.1107/S0907444903002208

実験手法

X-RAY DIFFRACTION (1.8 Å)