1B09

HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE

Summary for 1B09

• Entry DOI: 10.2210/pdb1b09/pdb
• Descriptor: PROTEIN (C-REACTIVE PROTEIN), CALCIUM ION, PHOSPHOCHOLINE (3 entities in total)
• Functional Keywords: pentraxin, acute-phase reactant, phosphocholine, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02741
• Total number of polymer chains: 5
• Total formula weight: 116661.73

Authors

Thompson, D.,Pepys, M.B.,Wood, S.P. (deposition date: 1998-11-18, release date: 1999-12-03, Last modification date: 2024-10-30)

Primary citation

Thompson, D.,Pepys, M.B.,Wood, S.P.
The physiological structure of human C-reactive protein and its complex with phosphocholine.
Structure Fold.Des., 7:169-177, 1999

PubMed Abstract: Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monitor many human diseases. However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest.

PubMed: 10368284
DOI: 10.1016/S0969-2126(99)80023-9

Experimental method

X-RAY DIFFRACTION (2.5 Å)