1B09

HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE

1B09 の概要

• エントリーDOI: 10.2210/pdb1b09/pdb
• 分子名称: PROTEIN (C-REACTIVE PROTEIN), CALCIUM ION, PHOSPHOCHOLINE (3 entities in total)
• 機能のキーワード: pentraxin, acute-phase reactant, phosphocholine, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02741
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 116661.73

構造登録者

Thompson, D.,Pepys, M.B.,Wood, S.P. (登録日: 1998-11-18, 公開日: 1999-12-03, 最終更新日: 2024-10-30)

主引用文献

Thompson, D.,Pepys, M.B.,Wood, S.P.
The physiological structure of human C-reactive protein and its complex with phosphocholine.
Structure Fold.Des., 7:169-177, 1999

PubMed Abstract: Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monitor many human diseases. However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest.

PubMed: 10368284
DOI: 10.1016/S0969-2126(99)80023-9

実験手法

X-RAY DIFFRACTION (2.5 Å)