1AZX

ANTITHROMBIN/PENTASACCHARIDE COMPLEX

1AZX の概要

• エントリーDOI: 10.2210/pdb1azx/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900031
• 分子名称: ANTITHROMBIN, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: serine protease inhibitor, serpin, antithrombin, anticoagulant activation by heparin
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space: P01008
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102188.48

構造登録者

Jin, L.,Abrahams, J.P.,Skinner, R.,Petitou, M.,Pike, R.N.,Carrell, R.W. (登録日: 1997-11-23, 公開日: 1999-01-13, 最終更新日: 2020-07-29)

• 主引用文献: Jin, L.,Abrahams, J.P.,Skinner, R.,Petitou, M.,Pike, R.N.,Carrell, R.W.; The anticoagulant activation of antithrombin by heparin.; Proc.Natl.Acad.Sci.USA, 94:14683-14688, 1997; PubMed: 9405673; DOI: 10.1073/pnas.94.26.14683

実験手法

X-RAY DIFFRACTION (2.9 Å)