1AZ2
CITRATE BOUND, C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE
Summary for 1AZ2
| Entry DOI | 10.2210/pdb1az2/pdb |
| Descriptor | ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID (3 entities in total) |
| Functional Keywords | oxidoreductase, aldo-keto reductase, inhibitor binding |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P15121 |
| Total number of polymer chains | 1 |
| Total formula weight | 36647.58 |
| Authors | Harrison, D.H.,Bohren, K.M.,Ringe, D.,Petsko, G.A.,Gabbay, K.H. (deposition date: 1997-11-24, release date: 1998-03-18, Last modification date: 2024-05-22) |
| Primary citation | Harrison, D.H.,Bohren, K.M.,Petsko, G.A.,Ringe, D.,Gabbay, K.H. The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant. Biochemistry, 36:16134-16140, 1997 Cited by PubMed: 9405046DOI: 10.1021/bi9717136 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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