1AYU
CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT SYMMETRIC BISCARBOHYDRAZIDE INHIBITOR
Summary for 1AYU
Entry DOI | 10.2210/pdb1ayu/pdb |
Descriptor | CATHEPSIN K, 1,5-BIS(N-BENZYLOXYCARBONYL-L-LEUCINYL)CARBOHYDRAZIDE (3 entities in total) |
Functional Keywords | hydrolase, sulfhydryl proteinase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 1 |
Total formula weight | 24108.14 |
Authors | Zhao, B.,Smith, W.W.,Janson, C.A.,Abdel-Meguid, S.S. (deposition date: 1997-11-10, release date: 1998-11-25, Last modification date: 2023-08-02) |
Primary citation | Thompson, S.K.,Halbert, S.M.,Bossard, M.J.,Tomaszek, T.A.,Levy, M.A.,Zhao, B.,Smith, W.W.,Abdel-Meguid, S.S.,Janson, C.A.,D'Alessio, K.J.,McQueney, M.S.,Amegadzie, B.Y.,Hanning, C.R.,DesJarlais, R.L.,Briand, J.,Sarkar, S.K.,Huddleston, M.J.,Ijames, C.F.,Carr, S.A.,Garnes, K.T.,Shu, A.,Heys, J.R.,Bradbeer, J.,Zembryki, D.,Lee-Rykaczewski, L.,James, I.E.,Lark, M.W.,Drake, F.H.,Gowen, M.,Gleason, J.G.,Veber, D.F. Design of potent and selective human cathepsin K inhibitors that span the active site. Proc.Natl.Acad.Sci.USA, 94:14249-14254, 1997 Cited by PubMed: 9405598DOI: 10.1073/pnas.94.26.14249 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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