1AYU

CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT SYMMETRIC BISCARBOHYDRAZIDE INHIBITOR

1AYU の概要

• エントリーDOI: 10.2210/pdb1ayu/pdb
• 分子名称: CATHEPSIN K, 1,5-BIS(N-BENZYLOXYCARBONYL-L-LEUCINYL)CARBOHYDRAZIDE (3 entities in total)
• 機能のキーワード: hydrolase, sulfhydryl proteinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P43235
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24108.14

構造登録者

Zhao, B.,Smith, W.W.,Janson, C.A.,Abdel-Meguid, S.S. (登録日: 1997-11-10, 公開日: 1998-11-25, 最終更新日: 2023-08-02)

• 主引用文献: Thompson, S.K.,Halbert, S.M.,Bossard, M.J.,Tomaszek, T.A.,Levy, M.A.,Zhao, B.,Smith, W.W.,Abdel-Meguid, S.S.,Janson, C.A.,D'Alessio, K.J.,McQueney, M.S.,Amegadzie, B.Y.,Hanning, C.R.,DesJarlais, R.L.,Briand, J.,Sarkar, S.K.,Huddleston, M.J.,Ijames, C.F.,Carr, S.A.,Garnes, K.T.,Shu, A.,Heys, J.R.,Bradbeer, J.,Zembryki, D.,Lee-Rykaczewski, L.,James, I.E.,Lark, M.W.,Drake, F.H.,Gowen, M.,Gleason, J.G.,Veber, D.F.; Design of potent and selective human cathepsin K inhibitors that span the active site.; Proc.Natl.Acad.Sci.USA, 94:14249-14254, 1997; PubMed: 9405598; DOI: 10.1073/pnas.94.26.14249

実験手法

X-RAY DIFFRACTION (2.2 Å)