1AYD

CRYSTAL STRUCTURES OF PEPTIDE COMPLEXES OF THE AMINO-TERMINAL SH2 DOMAIN OF THE SYP TYROSINE PHOSPHATASE

1AYD の概要

• エントリーDOI: 10.2210/pdb1ayd/pdb
• 分子名称: PROTEIN-TYROSINE PHOSPHATASE SYP (N-TERMINAL SH2 DOMAIN) (2 entities in total)
• 機能のキーワード: hydrolase(sh2 domain)
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cytoplasm: P35235
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11528.98

構造登録者

Lee, C.-H.,Kuriyan, J. (登録日: 1994-05-15, 公開日: 1994-08-31, 最終更新日: 2024-02-07)

主引用文献

Lee, C.H.,Kominos, D.,Jacques, S.,Margolis, B.,Schlessinger, J.,Shoelson, S.E.,Kuriyan, J.
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Structure, 2:423-438, 1994

PubMed Abstract: Src homology 2 (SH2) domains bind to phosphotyrosine residues in a sequence-specific manner, and thereby couple tyrosine phosphorylation to changes in the localization or catalytic activity of signal transducing molecules. Current understanding of SH2 specificity is based on the structures of SH2-peptide complexes of the closely-related Src and Lck tyrosine kinases. The tyrosine phosphatase Syp contains two SH2 domains that are relatively divergent from those of the tyrosine kinases, with distinct target specificities, and is thus well suited for structural studies aimed at extending our understanding of SH2 specificity.

PubMed: 7521735
DOI: 10.1016/S0969-2126(00)00044-7

実験手法

X-RAY DIFFRACTION (2.2 Å)