1AWC

MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA

1AWC の概要

• エントリーDOI: 10.2210/pdb1awc/pdb
• 分子名称: DNA (5'-D(*AP*AP*(BRU)P*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*AP*(CBR)P*AP*CP*(CBR)P*GP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*CP*GP*GP*(BRU)P*GP*(BRU)P*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP*AP*T)-3'), PROTEIN (GA BINDING PROTEIN ALPHA), ... (5 entities in total)
• 機能のキーワード: complex (transcription regulation-dna), dna-binding, nuclear protein, ets domain, ankyrin repeats, transcription factor, transcription-dna complex, transcription/dna
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Nucleus: Q00422 Q00420
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 43137.99

構造登録者

Batchelor, A.H.,Wolberger, C. (登録日: 1997-10-01, 公開日: 1998-03-18, 最終更新日: 2024-02-07)

主引用文献

Batchelor, A.H.,Piper, D.E.,de la Brousse, F.C.,McKnight, S.L.,Wolberger, C.
The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA.
Science, 279:1037-1041, 1998

PubMed Abstract: GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The alpha subunit contains a DNA-binding domain that is a member of the ETS family, whereas the beta subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2. 15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPalpha ETS domain binds to its core GGA DNA-recognition motif.

PubMed: 9461436
DOI: 10.1126/science.279.5353.1037

実験手法

X-RAY DIFFRACTION (2.15 Å)