1AVV

HIV-1 NEF PROTEIN, UNLIGANDED CORE DOMAIN

1AVV の概要

• エントリーDOI: 10.2210/pdb1avv/pdb
• 分子名称: NEGATIVE FACTOR (1 entity in total)
• 機能のキーワード: myristylation, gtp-binding, phosphorylation, hiv-1, nef, virus, pxxp motif
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Host cell membrane ; Lipid-anchor ; Cytoplasmic side : P03406
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17568.72

構造登録者

Arold, S.,Franken, P.,Dumas, C. (登録日: 1997-09-21, 公開日: 1998-03-25, 最終更新日: 2024-05-22)

主引用文献

Arold, S.,Franken, P.,Strub, M.P.,Hoh, F.,Benichou, S.,Benarous, R.,Dumas, C.
The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Structure, 5:1361-1372, 1997

PubMed Abstract: Human immunodeficiency virus (HIV) Nef protein accelerates virulent progression of acquired immunodeficiency syndrome (AIDS) by its interaction with specific cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src family of kinases. The structures of free Nef and Nef bound to Src homology region 3 (SH3) domain are important for the elucidation of how the affinity and specificity for the Src kinase family SH3 domains are achieved, and also for the development of potential drugs and vaccines against AIDS.

PubMed: 9351809
DOI: 10.1016/S0969-2126(97)00286-4

実験手法

X-RAY DIFFRACTION (3 Å)