1AV3

POTASSIUM CHANNEL BLOCKER KAPPA CONOTOXIN PVIIA FROM C. PURPURASCENS, NMR, 20 STRUCTURES

1AV3 の概要

• エントリーDOI: 10.2210/pdb1av3/pdb
• 分子名称: Kappa-conotoxin PVIIA (1 entity in total)
• 機能のキーワード: kappa-conotoxin, potassium channel blocker, cystine knot
• 由来する生物種: Conus purpurascens (Purple cone)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3282.87

構造登録者

Scanlon, M.J.,Naranjo, D.,Thomas, L.,Alewood, P.F.,Lewis, R.J.,Craik, D.J. (登録日: 1997-09-24, 公開日: 1998-10-14, 最終更新日: 2020-12-16)

主引用文献

Scanlon, M.J.,Naranjo, D.,Thomas, L.,Alewood, P.F.,Lewis, R.J.,Craik, D.J.
Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA.
Structure, 5:1585-1597, 1997

PubMed Abstract: kappa-PVIIA is a 27-residue polypeptide isolated from the venom of Conus purpurascens and is the first member of a new class of conotoxins that block potassium channels. By comparison to other ion channels of eukaryotic cell membranes, voltage-sensitive potassium channels are relatively simple and methodology has been developed for mapping their interactions with small-peptide toxins. PVIIA, therefore, is a valuable new probe of potassium channel structure. This study of the solution structure and mode of channel binding of PVIIA forms the basis for mapping the interacting residues at the conotoxin-ion channel interface.

PubMed: 9438859
DOI: 10.1016/S0969-2126(97)00307-9

実験手法

SOLUTION NMR