1AU4

CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PYRROLIDINONE INHIBITOR

1AU4 の概要

• エントリーDOI: 10.2210/pdb1au4/pdb
• 分子名称: CATHEPSIN K, 4-[[N-[(PHENYLMETHOXY)CARBONYL]-/NL/N-LEUCYL]AMINO]-1[(2S)-2-[[[4-(PYRIDINYLMETHOXY)CARBONYL]AMINO]-4-METHYLPENT/NYL]-3-PYRROLIDINONE/N (3 entities in total)
• 機能のキーワード: hydrolase, sulfhydryl proteinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P43235
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24105.18

構造登録者

Zhao, B.,Smith, W.W.,Janson, C.A.,Abdel-Meguid, S.S. (登録日: 1997-09-10, 公開日: 1998-10-14, 最終更新日: 2024-10-30)

• 主引用文献: Marquis, R.W.,Yamashita, D.S.,Ru, Y.,LoCastro, S.M.,Oh, H.J.,Erhard, K.F.,DesJarlais, R.L.,Head, M.S.,Smith, W.W.,Zhao, B.,Janson, C.A.,Abdel-Meguid, S.S.,Tomaszek, T.A.,Levy, M.A.,Veber, D.F.; Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K.; J.Med.Chem., 41:3563-3567, 1998; PubMed: 9733481; DOI: 10.1021/jm980295f

実験手法

X-RAY DIFFRACTION (2.3 Å)