1AU2
CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PROPANONE INHIBITOR
Summary for 1AU2
Entry DOI | 10.2210/pdb1au2/pdb |
Descriptor | CATHEPSIN K, 1-[[(4-PHENOXYPHENYL)SULFONYL]AMINO]-3-[[N/N-(4-PYRIDINYLCARBONYL)-L-LEUCYL]AMINO]-2-PROPANOL (3 entities in total) |
Functional Keywords | hydrolase, sulfhydryl proteinase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 1 |
Total formula weight | 24064.11 |
Authors | Zhao, B.,Smith, W.W.,Janson, C.A.,Abdel-Meguid, S.S. (deposition date: 1997-09-10, release date: 1998-10-14, Last modification date: 2023-08-02) |
Primary citation | Yamashita, D.S.,Smith, W.W.,Zhao, B.,Janson, C.A.,Tomaszek, T.A.,Bossard, M.J.,Levy, M.A.,Oh, H.-J.,Carr, T.J.,Thompson, S.K.,Ijames, C.F.,Carr, S.A.,Mcqueney, M.,D'Alessio, K.J.,Amegadzie, B.Y.,Hanning, C.R.,Abdel-Meguid, S.,Desjarlais, R.L.,Gleason, J.G.,Veber, D.F. Structure and Design of Potent and Selective Cathepsin K Inhibitors J.Am.Chem.Soc., 119:11351-11352, 1997 Cited by |
Experimental method |
Structure validation
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