1ATZ

HUMAN VON WILLEBRAND FACTOR A3 DOMAIN

1ATZ の概要

• エントリーDOI: 10.2210/pdb1atz/pdb
• 分子名称: VON WILLEBRAND FACTOR (2 entities in total)
• 機能のキーワード: collagen-binding, hemostasis, dinucleotide binding fold
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40303.96

構造登録者

Huizinga, E.G.,Gros, P. (登録日: 1997-08-15, 公開日: 1998-02-25, 最終更新日: 2024-10-23)

主引用文献

Huizinga, E.G.,Martijn van der Plas, R.,Kroon, J.,Sixma, J.J.,Gros, P.
Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding.
Structure, 5:1147-1156, 1997

PubMed Abstract: Bleeding from a damaged blood vessel is stopped by the formation of a platelet plug. The multimeric plasma glycoprotein, von Willebrand factor (vWF), plays an essential role in this process by anchoring blood platelets to the damaged vessel wall under conditions of high shear stress. This factor mediates platelet adhesion by binding both to collagen of the damaged blood vessel and to glycoprotein Ib on the platelet membrane. The A3 domain of vWF allows it to bind to collagen types I and III present in the perivascular connective tissue of the damaged vessel wall. To gain insight into the mechanism of collagen binding by vWF, we have determined the crystal structure of the human vWF A3 domain.

PubMed: 9331419
DOI: 10.1016/S0969-2126(97)00266-9

実験手法

X-RAY DIFFRACTION (1.8 Å)