1ATN

Atomic structure of the actin:DNASE I complex

1ATN の概要

• エントリーDOI: 10.2210/pdb1atn/pdb
• 分子名称: ACTIN, DEOXYRIBONUCLEASE I, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: endodeoxyribonuclease
• 由来する生物種: Oryctolagus cuniculus (rabbit); 詳細
• 細胞内の位置: Secreted: P00639
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71823.75

構造登録者

Kabsch, W.,Mannherz, H.G.,Suck, D.,Pai, E.,Holmes, K.C. (登録日: 1991-03-08, 公開日: 1992-07-15, 最終更新日: 2020-07-29)

主引用文献

Kabsch, W.,Mannherz, H.G.,Suck, D.,Pai, E.F.,Holmes, K.C.
Atomic structure of the actin:DNase I complex.
Nature, 347:37-44, 1990

PubMed Abstract: The atomic models of the complex between rabbit skeletal muscle actin and bovine pancreatic deoxyribonuclease I both in the ATP and ADP forms have been determined by X-ray analysis at an effective resolution of 2.8 A and 3A, respectively. The two structures are very similar. The actin molecule consists of two domains which can be further subdivided into two subdomains. ADP or ATP is located in the cleft between the domains with a calcium ion bound to the beta- or beta- and gamma-phosphates, respectively. The motif of a five-stranded beta sheet consisting of a beta meander and a right handed beta alpha beta unit appears in each domain suggesting that gene duplication might have occurred. These sheets have the same topology as that found in hexokinase.

PubMed: 2395459
DOI: 10.1038/347037a0

実験手法

X-RAY DIFFRACTION (2.8 Å)