1ASX

APICAL DOMAIN OF THE CHAPERONIN FROM THERMOPLASMA ACIDOPHILUM

1ASX の概要

• エントリーDOI: 10.2210/pdb1asx/pdb
• 関連するPDBエントリー: 1ASS
• 分子名称: THERMOSOME, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: chaperonin, hsp60, thermosome, tcp1, groel, thermoplasma acidophilum, atp-binding
• 由来する生物種: Thermoplasma acidophilum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17917.60

構造登録者

Klumpp, M.,Baumeister, W.,Essen, L.-O. (登録日: 1997-08-11, 公開日: 1997-12-03, 最終更新日: 2024-05-22)

主引用文献

Klumpp, M.,Baumeister, W.,Essen, L.O.
Structure of the substrate binding domain of the thermosome, an archaeal group II chaperonin.
Cell(Cambridge,Mass.), 91:263-270, 1997

PubMed Abstract: The crystal structure of the substrate binding domain of the thermosome, the archaeal group II chaperonin, has been determined at 2.3 A resolution. The core resembles the apical domain of GroEL but lacks the hydrophobic residues implied in binding of substrates to group I chaperonins. Rather, a large hydrophobic surface patch is found in a novel helix-turn-helix motif, which is characteristic of all group II chaperonins including the eukaryotic TRiC/CCT complex. Models of the holochaperonin, which are consistent with cryo electron microscopy data, suggest a dual role of this helical protrusion in substrate binding and controlling access to the central cavity independent of a GroES-like cochaperonin.

PubMed: 9346243
DOI: 10.1016/S0092-8674(00)80408-0

実験手法

X-RAY DIFFRACTION (2.8 Å)