1AQ5

HIGH-RESOLUTION SOLUTION NMR STRUCTURE OF THE TRIMERIC COILED-COIL DOMAIN OF CHICKEN CARTILAGE MATRIX PROTEIN, 20 STRUCTURES

1AQ5 の概要

• エントリーDOI: 10.2210/pdb1aq5/pdb
• 分子名称: CARTILAGE MATRIX PROTEIN (1 entity in total)
• 機能のキーワード: coiled-coil, heptad repeat, interchain disulfide bonds, oligomerization domain, trimer, cartilage matrix protein, matrilin-1, noncollagenous extracellular protein
• 由来する生物種: Gallus gallus (chicken)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 16179.76

構造登録者

Dames, S.A.,Wiltscheck, R.,Kammerer, R.A.,Engel, J.,Alexandrescu, A.T. (登録日: 1997-08-07, 公開日: 1998-02-11, 最終更新日: 2024-11-06)

主引用文献

Dames, S.A.,Kammerer, R.A.,Wiltscheck, R.,Engel, J.,Alexandrescu, A.T.
NMR structure of a parallel homotrimeric coiled coil.
Nat.Struct.Biol., 5:687-691, 1998

PubMed Abstract: The solution structure of the oligomerization domain of cartilage matrix protein (also known as matrilin-1) has been determined by heteronuclear NMR spectroscopy. The domain folds into a parallel, disulfide-linked, three-stranded, alpha-helical coiled coil, spanning five heptad repeats in the amino acid sequence. The sequence of the first two heptad repeats shows some deviations from the consensus of hydrophobic and hydrophilic residue preferences. While the corresponding region of the coiled coil has a higher intrinsic flexibility, backbone alpha-helix and superhelix parameters are consistent with a regular coiled coil structure.

PubMed: 9699631
DOI: 10.1038/1382

実験手法

SOLUTION NMR