1AQ1

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE

Summary for 1AQ1

• Entry DOI: 10.2210/pdb1aq1/pdb
• Descriptor: CYCLIN-DEPENDENT PROTEIN KINASE 2, STAUROSPORINE (3 entities in total)
• Functional Keywords: protein kinase, cell cycle, phosphorylation, staurosporine, cell division, mitosis, inhibition
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 34443.02

Authors

Endicott, J.A.,Noble, M.E.M.,Johnson, L.N.,Lawrie, A.,Tunnah, P.,Brown, N.R. (deposition date: 1997-08-05, release date: 1997-11-12, Last modification date: 2024-05-22)

Primary citation

Lawrie, A.M.,Noble, M.E.,Tunnah, P.,Brown, N.R.,Johnson, L.N.,Endicott, J.A.
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
Nat.Struct.Biol., 4:796-801, 1997

PubMed Abstract: Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.

PubMed: 9334743
DOI: 10.1038/nsb1097-796

Experimental method

X-RAY DIFFRACTION (2 Å)