1AQ1

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE

Summary for 1AQ1

DescriptorCYCLIN-DEPENDENT PROTEIN KINASE 2, STAUROSPORINE (3 entities in total)
Functional Keywordsprotein kinase, cell cycle, phosphorylation, staurosporine, cell division, mitosis, inhibition
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34443.02
Authors
Endicott, J.A.,Noble, M.E.M.,Johnson, L.N.,Lawrie, A.,Tunnah, P.,Brown, N.R. (deposition date: 1997-08-05, release date: 1997-11-12, Last modification date: 2011-07-13)
Primary citation
Lawrie, A.M.,Noble, M.E.,Tunnah, P.,Brown, N.R.,Johnson, L.N.,Endicott, J.A.
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
Nat.Struct.Biol., 4:796-801, 1997
PubMed: 9334743 (PDB entries with the same primary citation)
DOI: 10.1038/nsb1097-796
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2521005.7%5.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report