1APC

SOLUTION STRUCTURE OF APOCYTOCHROME B562

1APC の概要

• エントリーDOI: 10.2210/pdb1apc/pdb
• 分子名称: CYTOCHROME B562 (1 entity in total)
• 機能のキーワード: electron transport
• 由来する生物種: Escherichia coli
• 細胞内の位置: Periplasm : P0ABE7
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11799.24

構造登録者

Wand, A.J.,Feng, Y.,Sligar, S.G. (登録日: 1993-10-14, 公開日: 1994-01-31, 最終更新日: 2024-04-10)

主引用文献

Feng, Y.,Sligar, S.G.,Wand, A.J.
Solution structure of apocytochrome b562.
Nat.Struct.Biol., 1:30-35, 1994

PubMed Abstract: The apoprotein is an important intermediate on the folding pathways of many haem proteins, yet a detailed structure of such an intermediate has remained elusive. Here we present the structure of apocytochrome b562 obtained by NMR spectroscopy. The apoprotein has a topology similar to the holoprotein. Nevertheless, significant differences in helix-helix packing between the two are evident. Much of the haem binding pocket in the apoprotein is preserved but exposed to solvent creating a large cavern. As apocytochrome b562 displays many of the physical characteristics ascribed to the molten globule state, these results help ellucidate the origin of several properties of the protein molten globule.

PubMed: 7656004
DOI: 10.1038/nsb0194-30

実験手法

SOLUTION NMR