1AP0

STRUCTURE OF THE CHROMATIN BINDING (CHROMO) DOMAIN FROM MOUSE MODIFIER PROTEIN 1, NMR, 26 STRUCTURES

1AP0 の概要

• エントリーDOI: 10.2210/pdb1ap0/pdb
• 分子名称: MODIFIER PROTEIN 1 (1 entity in total)
• 機能のキーワード: chromatin-binding, protein interaction motif, alpha+beta
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Nucleus (By similarity): P83917
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8694.56

構造登録者

Ball, L.J.,Murzina, N.V.,Broadhurst, R.W.,Raine, A.R.C.,Archer, S.J.,Stott, F.J.,Murzin, A.G.,Singh, P.B.,Domaille, P.J.,Laue, E.D. (登録日: 1997-07-22, 公開日: 1998-07-22, 最終更新日: 2024-05-22)

主引用文献

Ball, L.J.,Murzina, N.V.,Broadhurst, R.W.,Raine, A.R.,Archer, S.J.,Stott, F.J.,Murzin, A.G.,Singh, P.B.,Domaille, P.J.,Laue, E.D.
Structure of the chromatin binding (chromo) domain from mouse modifier protein 1.
EMBO J., 16:2473-2481, 1997

PubMed Abstract: The structure of a chromatin binding domain from mouse chromatin modifier protein 1 (MoMOD1) was determined using nuclear magnetic resonance (NMR) spectroscopy. The protein consists of an N-terminal three-stranded anti-parallel beta-sheet which folds against a C-terminal alpha-helix. The structure reveals an unexpected homology to two archaebacterial DNA binding proteins which are also involved in chromatin structure. Structural comparisons suggest that chromo domains, of which more than 40 are now known, act as protein interaction motifs and that the MoMOD1 protein acts as an adaptor mediating interactions between different proteins.

PubMed: 9171360
DOI: 10.1093/emboj/16.9.2473

実験手法

SOLUTION NMR