1AOT

NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, MINIMIZED AVERAGE STRUCTURE

1AOT の概要

• エントリーDOI: 10.2210/pdb1aot/pdb
• 関連するPDBエントリー: 1AOU
• 分子名称: FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE (2 entities in total)
• 機能のキーワード: sh2 domain, signal transduction, peptide complex, complex (proto-oncogene-early protein), complex (proto-oncogene-early protein) complex, complex (proto-oncogene/early protein)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane: P06241; Host membrane; Single-pass membrane protein (Potential): P03079
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 13773.33

構造登録者

Mulhern, T.D.,Shaw, G.L.,Morton, C.J.,Day, A.J.,Campbell, I.D. (登録日: 1997-07-10, 公開日: 1998-01-14, 最終更新日: 2021-11-03)

• 主引用文献: Mulhern, T.D.,Shaw, G.L.,Morton, C.J.,Day, A.J.,Campbell, I.D.; The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.; Structure, 5:1313-1323, 1997; PubMed: 9351806; DOI: 10.1016/S0969-2126(97)00283-9

実験手法

SOLUTION NMR