1AOL

FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN

1AOL の概要

• エントリーDOI: 10.2210/pdb1aol/pdb
• 分子名称: GP70, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (4 entities in total)
• 機能のキーワード: coat protein, viral glycoprotein, retrovirus, viral protein
• 由来する生物種: Friend murine leukemia virus
• 細胞内の位置: Transmembrane protein: Virion membrane; Single-pass type I membrane protein (By similarity). Surface protein: Virion membrane; Peripheral membrane protein. R-peptide: Host cell membrane; Peripheral membrane protein (By similarity): P03390
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26036.00

構造登録者

Fass, D.,Davey, R.A.,Hamson, C.A.,Kim, P.S.,Cunningham, J.M.,Berger, J.M. (登録日: 1997-07-08, 公開日: 1997-10-15, 最終更新日: 2024-11-06)

主引用文献

Fass, D.,Davey, R.A.,Hamson, C.A.,Kim, P.S.,Cunningham, J.M.,Berger, J.M.
Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution.
Science, 277:1662-1666, 1997

PubMed Abstract: An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to 2.0 angstrom resolution by x-ray crystallography. The core of the domain is an antiparallel beta sandwich, with two interstrand loops forming a helical subdomain atop the sandwich. The residues in the helical region, but not in the beta sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus.

PubMed: 9287219
DOI: 10.1126/science.277.5332.1662

実験手法

X-RAY DIFFRACTION (2 Å)