1AOI

COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT

1AOI の概要

• エントリーDOI: 10.2210/pdb1aoi/pdb
• 分子名称: PALINDROMIC 146 BP DNA REPEAT 8/9 FROM HUMAN X-CHROMOSOME ALPHA SATELLITE DNA, HISTONE H3, HISTONE H4, ... (7 entities in total)
• 機能のキーワード: nucleosome, chromatin, histone, protein dna interaction, nucleoprotein, supercoiled dna, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Xenopus laevis (African clawed frog); 詳細
• 細胞内の位置: Nucleus: P02302 P62799 P06897 P02281
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 184547.40

構造登録者

Luger, K.,Maeder, A.W.,Richmond, R.K.,Sargent, D.F.,Richmond, T.J. (登録日: 1997-07-03, 公開日: 1998-09-30, 最終更新日: 2024-02-07)

主引用文献

Luger, K.,Mader, A.W.,Richmond, R.K.,Sargent, D.F.,Richmond, T.J.
Crystal structure of the nucleosome core particle at 2.8 A resolution.
Nature, 389:251-260, 1997

PubMed Abstract: The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it. Both histone/histone and histone/DNA interactions depend on the histone fold domains and additional, well ordered structure elements extending from this motif. Histone amino-terminal tails pass over and between the gyres of the DNA superhelix to contact neighbouring particles. The lack of uniformity between multiple histone/DNA-binding sites causes the DNA to deviate from ideal superhelix geometry.

PubMed: 9305837
DOI: 10.1038/38444

実験手法

X-RAY DIFFRACTION (2.8 Å)