1AO7

COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201

1AO7 の概要

• エントリーDOI: 10.2210/pdb1ao7/pdb
• 分子名称: HLA-A 0201, BETA-2 MICROGLOBULIN, TAX PEPTIDE, ... (7 entities in total)
• 機能のキーワード: class i mhc, t-cell receptor, viral peptide, complex (mhc-viral peptide-receptor, complex (mhc-viral peptide-receptor) complex, complex (mhc/viral peptide/receptor)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted : P61769; Host nucleus : P14079
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 95026.00

構造登録者

Garboczi, D.N.,Ghosh, P.,Utz, U.,Fan, Q.R.,Biddison, W.E.,Wiley, D.C. (登録日: 1997-07-21, 公開日: 1997-09-17, 最終更新日: 2024-11-20)

主引用文献

Garboczi, D.N.,Ghosh, P.,Utz, U.,Fan, Q.R.,Biddison, W.E.,Wiley, D.C.
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.
Nature, 384:134-141, 1996

PubMed Abstract: Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.

PubMed: 8906788
DOI: 10.1038/384134a0

実験手法

X-RAY DIFFRACTION (2.6 Å)