1ANT

BIOLOGICAL IMPLICATIONS OF A 3 ANGSTROMS STRUCTURE OF DIMERIC ANTITHROMBIN

Summary for 1ANT

Entry DOI	10.2210/pdb1ant/pdb
Descriptor	ANTITHROMBIN (1 entity in total)
Functional Keywords	serine protease inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space: P01008
Total number of polymer chains	2
Total formula weight	98202.03
Authors	Carrell, R.W.,Stein, P.E.,Fermi, G.,Wardell, M.R. (deposition date: 1994-02-28, release date: 1995-01-26, Last modification date: 2024-10-23)
Primary citation	Carrell, R.W.,Stein, P.E.,Fermi, G.,Wardell, M.R. Biological implications of a 3 A structure of dimeric antithrombin. Structure, 2:257-270, 1994 Cited by PubMed Abstract: Antithrombin, a member of the serpin family of inhibitors, controls coagulation in human plasma by forming complexes with thrombin and other coagulation proteases in a process greatly accelerated by heparin. The structures of several serpins have been determined but not in their active conformations. We have determined the structure of intact antithrombin in order to study its mechanism of activation, particularly with respect to heparin, and the dysfunctions of this mechanism that predispose individuals to thrombotic disease. PubMed: 8087553 DOI: 10.1016/S0969-2126(00)00028-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation