1ANT

BIOLOGICAL IMPLICATIONS OF A 3 ANGSTROMS STRUCTURE OF DIMERIC ANTITHROMBIN

1ANT の概要

• エントリーDOI: 10.2210/pdb1ant/pdb
• 分子名称: ANTITHROMBIN (1 entity in total)
• 機能のキーワード: serine protease inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space: P01008
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98202.03

構造登録者

Carrell, R.W.,Stein, P.E.,Fermi, G.,Wardell, M.R. (登録日: 1994-02-28, 公開日: 1995-01-26, 最終更新日: 2024-10-23)

主引用文献

Carrell, R.W.,Stein, P.E.,Fermi, G.,Wardell, M.R.
Biological implications of a 3 A structure of dimeric antithrombin.
Structure, 2:257-270, 1994

PubMed Abstract: Antithrombin, a member of the serpin family of inhibitors, controls coagulation in human plasma by forming complexes with thrombin and other coagulation proteases in a process greatly accelerated by heparin. The structures of several serpins have been determined but not in their active conformations. We have determined the structure of intact antithrombin in order to study its mechanism of activation, particularly with respect to heparin, and the dysfunctions of this mechanism that predispose individuals to thrombotic disease.

PubMed: 8087553
DOI: 10.1016/S0969-2126(00)00028-9

実験手法

X-RAY DIFFRACTION (3 Å)