1ALY

CRYSTAL STRUCTURE OF HUMAN CD40 LIGAND

Summary for 1ALY

• Entry DOI: 10.2210/pdb1aly/pdb
• Descriptor: CD40 LIGAND (2 entities in total)
• Functional Keywords: cd40l, cd40 ligand, cytokine, tnf, hyper-igm syndrome
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type II membrane protein. CD40 ligand, soluble form: Secreted: P29965
• Total number of polymer chains: 1
• Total formula weight: 15812.82

Authors

Karpusas, M.,Hsu, Y.M.,Thomas, D. (deposition date: 1997-06-05, release date: 1997-09-17, Last modification date: 2024-04-03)

Primary citation

Karpusas, M.,Hsu, Y.M.,Wang, J.H.,Thompson, J.,Lederman, S.,Chess, L.,Thomas, D.
2 A crystal structure of an extracellular fragment of human CD40 ligand.
Structure, 3:1031-1039, 1995

PubMed Abstract: The CD40 ligand (CD40L) is a member of the tumor necrosis factor (TNF) family of proteins and is transiently expressed on the surface of activated T cells. The binding of CD40L to CD40, which is expressed on the surface of B cells, provides a critical and unique pathway of cellular activation resulting in antibody isotype switching, regulation of apoptosis, and B cell proliferation and differentiation. Naturally occurring mutations of CD40L result in the clinical hyper-IgM syndrome, characterized by an inability to produce immunoglobulins of the IgG, IgA and IgE isotypes.

PubMed: 8589998
DOI: 10.1016/S0969-2126(01)00239-8

Experimental method

X-RAY DIFFRACTION (2 Å)