1AJ6
NOVOBIOCIN-RESISTANT MUTANT (R136H) OF THE N-TERMINAL 24 KDA FRAGMENT OF DNA GYRASE B COMPLEXED WITH NOVOBIOCIN AT 2.3 ANGSTROMS RESOLUTION
Summary for 1AJ6
Entry DOI | 10.2210/pdb1aj6/pdb |
Descriptor | GYRASE, NOVOBIOCIN (3 entities in total) |
Functional Keywords | topoisomerase, gyrase, novobiocin, antibiotic, resistant mutant |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 24653.56 |
Authors | Weston, S.A.,Tunnicliffe, A.,Pauptit, R.A. (deposition date: 1997-05-15, release date: 1998-05-20, Last modification date: 2024-04-03) |
Primary citation | Holdgate, G.A.,Tunnicliffe, A.,Ward, W.H.,Weston, S.A.,Rosenbrock, G.,Barth, P.T.,Taylor, I.W.,Pauptit, R.A.,Timms, D. The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study. Biochemistry, 36:9663-9673, 1997 Cited by PubMed: 9245398DOI: 10.1021/bi970294+ PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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