1AJ6

NOVOBIOCIN-RESISTANT MUTANT (R136H) OF THE N-TERMINAL 24 KDA FRAGMENT OF DNA GYRASE B COMPLEXED WITH NOVOBIOCIN AT 2.3 ANGSTROMS RESOLUTION

1AJ6 の概要

• エントリーDOI: 10.2210/pdb1aj6/pdb
• 分子名称: GYRASE, NOVOBIOCIN (3 entities in total)
• 機能のキーワード: topoisomerase, gyrase, novobiocin, antibiotic, resistant mutant
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24653.56

構造登録者

Weston, S.A.,Tunnicliffe, A.,Pauptit, R.A. (登録日: 1997-05-15, 公開日: 1998-05-20, 最終更新日: 2024-04-03)

• 主引用文献: Holdgate, G.A.,Tunnicliffe, A.,Ward, W.H.,Weston, S.A.,Rosenbrock, G.,Barth, P.T.,Taylor, I.W.,Pauptit, R.A.,Timms, D.; The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study.; Biochemistry, 36:9663-9673, 1997; PubMed: 9245398; DOI: 10.1021/bi970294+

実験手法

X-RAY DIFFRACTION (2.3 Å)