1AI8

HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROMPG

1AI8 の概要

• エントリーDOI: 10.2210/pdb1ai8/pdb
• 分子名称: ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUDIN IIIB, ... (5 entities in total)
• 機能のキーワード: serine proteinase, blood coagulation, hydrolase-hydrolase inhibitor complex, blood coagulation-hydrolase inhibitor complex, blood coagulation/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 36061.83

構造登録者

Skordalakes, E.,Dodson, G.,Elgendy, S.,Goodwin, C.A.,Green, D.,Tyrrel, R.,Scully, M.F.,Freyssinet, J.,Kakkar, V.V.,Deadman, J. (登録日: 1997-05-01, 公開日: 1997-10-15, 最終更新日: 2023-08-02)

• 主引用文献: Bode, W.,Turk, D.,Karshikov, A.; The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.; Protein Sci., 1:426-471, 1992; PubMed: 1304349

実験手法

X-RAY DIFFRACTION (1.85 Å)