1AH4

PIG ALDOSE REDUCTASE, HOLO FORM

1AH4 の概要

• エントリーDOI: 10.2210/pdb1ah4/pdb
• 分子名称: ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
• 機能のキーワード: oxidoreductase, aldose reductase, inhibition, diabetes
• 由来する生物種: Sus scrofa (pig)
• 細胞内の位置: Cytoplasm: P80276
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36567.44

構造登録者

Moras, D.,Podjarny, A. (登録日: 1997-04-12, 公開日: 1998-04-15, 最終更新日: 2024-04-03)

主引用文献

Urzhumtsev, A.,Tete-Favier, F.,Mitschler, A.,Barbanton, J.,Barth, P.,Urzhumtseva, L.,Biellmann, J.F.,Podjarny, A.,Moras, D.
A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil.
Structure, 5:601-612, 1997

PubMed Abstract: Aldose reductase (AR) is an NADPH-dependent enzyme implicated in long-term diabetic complications. Buried at the bottom of a deep hydrophobic cleft, the NADPH coenzyme is surrounded by the conserved hydrophilic residues of the AR active site. The existence of an anionic binding site near the NADP+ has been determined from the structures of the complexes of AR with citrate, cacodylate and glucose-6-phosphate. The inhibitor zopolrestat binds to this anionic site, and in the hydrophobic cleft, after a change of conformation which opens a 'specificity' pocket.

PubMed: 9195881
DOI: 10.1016/S0969-2126(97)00216-5

実験手法

X-RAY DIFFRACTION (2 Å)