1AGW

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR

1AGW の概要

• エントリーDOI: 10.2210/pdb1agw/pdb
• 分子名称: FGF RECEPTOR 1, 3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE (3 entities in total)
• 機能のキーワード: protein kinase, transferase, tyrosine-protein kinase, atp-binding, phosphorylation, inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P11362
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71288.03

構造登録者

Mohammadi, M.,Schlessinger, J.,Hubbard, S.R. (登録日: 1997-03-25, 公開日: 1998-03-25, 最終更新日: 2024-02-07)

• 主引用文献: Mohammadi, M.,McMahon, G.,Sun, L.,Tang, C.,Hirth, P.,Yeh, B.K.,Hubbard, S.R.,Schlessinger, J.; Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.; Science, 276:955-960, 1997; PubMed: 9139660; DOI: 10.1126/science.276.5314.955

実験手法

X-RAY DIFFRACTION (2.4 Å)