1AG7

CONOTOXIN GS, NMR, 20 STRUCTURES

1AG7 の概要

• エントリーDOI: 10.2210/pdb1ag7/pdb
• 分子名称: CONOTOXIN GS (1 entity in total)
• 機能のキーワード: neurotoxin, mu-conotoxin, sodium channel blocker, cystine knot motif
• 由来する生物種: Conus geographus (geography cone)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3630.15

構造登録者

Hill, J.M.,Alewood, P.F.,Craik, D.J. (登録日: 1997-04-03, 公開日: 1998-04-08, 最終更新日: 2022-02-16)

主引用文献

Hill, J.M.,Alewood, P.F.,Craik, D.J.
Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry.
Structure, 5:571-583, 1997

PubMed Abstract: The venoms of Conus snails contain small, disulfide-rich inhibitors of voltage-dependent sodium channels. Conotoxin GS is a 34-residue polypeptide isolated from Conus geographus that interacts with the extracellular entrance of skeletal muscle sodium channels to prevent sodium ion conduction. Although conotoxin GS binds competitively with mu conotoxin GIIIA to the sodium channel surface, the two toxin types have little sequence identity with one another, and conotoxin GS has a four-loop structural framework rather than the characteristic three-loop mu-conotoxin framework. The structural study of conotoxin GS will form the basis for establishing a structure-activity relationship and understanding its interaction with the pore region of sodium channels.

PubMed: 9115446
DOI: 10.1016/S0969-2126(97)00212-8

実験手法

SOLUTION NMR