1ADU

EARLY E2A DNA-BINDING PROTEIN

Summary for 1ADU

• Entry DOI: 10.2210/pdb1adu/pdb
• Descriptor: ADENOVIRUS SINGLE-STRANDED DNA-BINDING PROTEIN, ZINC ION (2 entities in total)
• Functional Keywords: dna-binding protein, ssdna binding protein, dna binding protein
• Biological source: Human adenovirus 5
• Total number of polymer chains: 2
• Total formula weight: 80061.13

Authors

Tucker, P.A.,Kanellopoulos, P.N.,Tsernoglou, D.,Van Der Vliet, P.C. (deposition date: 1995-05-11, release date: 1996-06-20, Last modification date: 2024-02-07)

Primary citation

Kanellopoulos, P.N.,Tsernoglou, D.,van der Vliet, P.C.,Tucker, P.A.
Alternative arrangements of the protein chain are possible for the adenovirus single-stranded DNA binding protein.
J.Mol.Biol., 257:1-8, 1996

PubMed Abstract: A second crystal form of the C-terminal domain of the adenovirus single-stranded DNA binding protein crystallizes in space group P2(1)2(1)2(1) with a=61.0 angstrom, b=91.2 angstrom and c=149.4 angstrom. The crystals contain two molecules per asymmetric unit and diffract to a maximum resolution of 3.0 angstrom. The crystal is composed of infinite chains of molecules along the crystallographic 2(1) axis parallel to c. The principal intermolecular interaction is a hooking of the C-terminal 17 residues of one molecule onto the next molecule in the protein chain. Adjacent molecules in the chain are rotated approximately 90 degrees with respect to their neighbours. The difference in relative orientation of adjacent molecules between the two crystal forms of the protein implies a degree of flexibility in the protein chain that would facilitate DNA binding.

PubMed: 8632448
DOI: 10.1006/jmbi.1996.0141

Experimental method

X-RAY DIFFRACTION (3 Å)